p-Toluenesulfonic acid → 2-(2-((2-Bromobenzyl)oxy)ethoxy)tetrahydro-2H-pyran

HRID 1797288Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1797288
[Br:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10]OC1CCCCO1.[O:22]1C=C[CH2:25][CH2:24][CH2:23]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1COCC1>[Br:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][O:8][CH:9]1[CH2:10][CH2:25][CH2:24][CH2:23][O:22]1

Komponenten

5

Edukt 3

HCID 6101p-Toluenesulfonic acidHCID 80803,4-dihydro-2H-pyranHCID 99469012-(2-(2-((2-Bromobenzyl)oxy)ethoxy)ethoxy)tetrahydro-2H-pyran

Produkt 1

HCID 98798912-(2-((2-Bromobenzyl)oxy)ethoxy)tetrahydro-2H-pyran

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The reaction and work up was conducted as described in the preparation of compound 420. Starting materials were compound 417 (8.0 g, 34.9 mmol) in 20 mL dry THF, 3,4-dihydro-2H-pyran (3.2 mL, 34.9 mmol) and p-toluenesulfonic acid (0.14 g, 0.76 mmol) and the reaction time was 4 h. The crude product was purified by flash chromatography using EtOAc/petroleum ether 1:2 as the eluent to afford the title compound as a colourless oil.

Aufarbeitung

  1. customThe reaction and work
  2. customThe crude product was purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-d7373535b1aa415e9b08da7c5f3d7216
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07034015B2

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