3,4,5-Trimethyl-piperazine-1-carboxylic acid benzyl ester → 1,2,6-Trimethylpiperazine

HRID 1798551Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1798551
C(OC([N:11]1[CH2:16][CH:15]([CH3:17])[N:14]([CH3:18])[CH:13]([CH3:19])[CH2:12]1)=O)C1C=CC=CC=1>CCO.[Pd]>[CH3:18][N:14]1[CH:15]([CH3:17])[CH2:16][NH:11][CH2:12][CH:13]1[CH3:19]

Komponenten

4

Edukt 1

HCID 687346163,4,5-Trimethyl-piperazine-1-carboxylic acid benzyl ester

Produkt 1

HCID 219737471,2,6-Trimethylpiperazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Under an inert atmosphere of nitrogen, 3,4,5-trimethyl-piperazine-1-carboxylic acid benzyl ester (1 eq, 1.87 mmol, 0.49 g) is dissolved in EtOH (20 ml) and palladium on carbon (0.1 eq, 0.187 mmol, 0.2 g) is added. The reaction is stirred at room temperature under an atmosphere of hydrogen for 4 hrs. The reaction mixture is filtered through Celite® and the solvent evaporated under vacuo to afford the title compound.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered through Celite®
  2. customthe solvent evaporated under vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3078ad1b2ace4a1baf621956ef064d5c
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08343966B2

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