Ethylamine → N-{2-(Ethylamino)-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide

HRID 1799279

Reaktionsgleichung

Reaktionsgleichung von HRID 1799279
[F:1][C:2]([F:32])([F:31])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11]([NH:15][C:16](=[O:30])[C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[CH:19][CH:18]=2)[C:12](O)=[O:13])=[CH:6][CH:5]=1.[CH2:33]([NH2:35])[CH3:34]>>[CH2:33]([NH:35][C:12](=[O:13])[CH:11]([NH:15][C:16](=[O:30])[C:17]1[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[CH:19][CH:18]=1)[CH2:10][C:7]1[CH:6]=[CH:5][C:4]([O:3][C:2]([F:32])([F:31])[F:1])=[CH:9][CH:8]=1)[CH3:34]

Komponenten

3

Edukt 2

HCID 6341EthylamineHCID 780686233-[4-(Trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoic acid

Produkt 1

HCID 57972154N-{2-(Ethylamino)-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide

Versuchsvorschrift

A reaction similar to that described in Example 32 (32c) was conducted using 3-[4-(trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoic acid (139 mg) prepared in Example 70 (70a) and ethylamine (30 μL, 70% aqueous solution) to give 106 mg of the title compound (white powder).

Aufarbeitung

  1. customA reaction similar to

Quellen und Nachweise

ORD-Eintrag
ord-eb66e1a88cb445f085834ca661c76945
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344029B2

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