Dimethylformamide → 3-(1-Cyanocyclopropyl)benzoyl chloride

HRID 1800386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1800386
[C:1]([C:3]1([C:6]2[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=2)[C:9](O)=[O:10])[CH2:5][CH2:4]1)#[N:2].C(Cl)(=O)C([Cl:18])=O.CN(C)C=O>O1CCCC1>[C:1]([C:3]1([C:6]2[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=2)[C:9]([Cl:18])=[O:10])[CH2:5][CH2:4]1)#[N:2]

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 574410393-(1-Cyanocyclopropyl)benzoic acid

Produkt 1

HCID 866319823-(1-Cyanocyclopropyl)benzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 3-(1-cyanocyclopropyl)benzoic acid (2.6 g, 13.9 mmol) in tetrahydrofuran (60 mL) were added oxalyl chloride (1.63 mL, 19.1 mmol) and N,N-dimethylformamide (about 20 μL), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure to give 3-(1-cyanocyclopropyl)benzoyl chloride as a colorless oil.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-88737fc1762b4d08993be9a7d2119bd2
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08344135B2

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