Water → 4-(3-(3-Carboxypropanoyl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-7-yl)benzoic acid

HRID 1801983Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1801983
C([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:23]=[C:22]3[C:17]([C:18]([OH:33])=[C:19]([C:26](=[O:32])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])[C:20](=[O:25])[N:21]3[CH3:24])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)=[O:7])(C)(C)C.OC1C2C(=CC(C3C=CC(C(OC(C)(C)C)=O)=CC=3)=CC=2)N(C)C(=O)C=1C(=O)CCC=O.OOS([O-])=O.[K+].O>CN(C=O)C>[C:29]([CH2:28][CH2:27][C:26]([C:19]1[C:20](=[O:25])[N:21]([CH3:24])[C:22]2[C:17]([C:18]=1[OH:33])=[CH:16][CH:15]=[C:14]([C:11]1[CH:10]=[CH:9][C:8]([C:6]([OH:7])=[O:5])=[CH:13][CH:12]=1)[CH:23]=2)=[O:32])([OH:31])=[O:30]

Komponenten

6

Edukt 4

HCID 962WaterHCID 23707502Potassium hydroxy sulfiteHCID 67407862HCID 67407862, VerbindungHCID 86631268HCID 86631268, Verbindung

Produkt 1

HCID 547473424-(3-(3-Carboxypropanoyl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-7-yl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-(7-(4-(tert-Butoxycarbonyl)phenyl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-4-oxobutanoic acid. tert-Butyl 4-(4-hydroxy-1-methyl-2-oxo-3-(4-oxobutanoyl)-1,2-dihydroquinolin-7-yl)benzoate (130 mg, 299 mmol) was dissolved in DMF (1493 n1). Oxone (184 mg, 299 mmol) was added to the mixture at room temperature, and the resulting mixture was stirred for 1 hour. Water was added to precipitate the product from solution. The mixture was filtered, washed with water and ether, and dried in a vacuum oven to give the title compound as an off-white solid.

Aufarbeitung

  1. customto precipitate the product from solution
  2. filtrationThe mixture was filtered
  3. washwashed with water and ether
  4. customdried in a vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-afb23809989f453f87f30f30d96fff6f
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08349868B2

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