Isopropyl isocyanate → HCID 44223274, Verbindung

HRID 1803076Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1803076
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][CH:19]=[CH:18][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([NH2:17])[CH:13]=2)[N:8]=1.[CH:22]([N:25]=[C:26]=[O:27])([CH3:24])[CH3:23]>C1(C)C=CC=CC=1>[CH:22]([NH:25][C:26]([NH:17][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:6][CH2:5][C:4]1[CH:18]=[CH:19][CH:20]=[CH:21][C:3]=1[O:2][CH3:1])[CH:16]=[CH:15]2)=[O:27])([CH3:24])[CH3:23]

Komponenten

4

Edukt 2

HCID 61277Isopropyl isocyanateHCID 43450845N2-(2-Methoxy-benzyl)-quinoline-2,6-diamine

Produkt 1

HCID 44223274HCID 44223274, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

N2-(2-Methoxy-benzyl)-quinoline-2,6-diamine (example 10, step B, 50 mg, 0.179 mmol) was dissolved in 1 mL toluene. Isopropyl isocyanate (15 mg, 0.179 mmol) was added and the reaction mixture was stirred at 60° C. overnight. The reaction mixture was cooled to room temperature and the crystals were filtered off and washed with dichloromethane. The title compound was obtained as an off-white solid (24 mg, 37%), MS: m/e=365.3 (M+H+).

Aufarbeitung

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationthe crystals were filtered off
  3. washwashed with dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-a0491bfda1024af0ae7e853c6a3fd26d
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08350028B2

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