6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804020

Reaktionsgleichung

Reaktionsgleichung von HRID 1804020
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:11][C:12]1[C:13]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:14][CH:15]=[C:16]([CH3:18])[CH:17]=1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[C:12]([CH3:11])=[CH:17][C:16]([CH3:18])=[CH:15][N:14]=3)[CH2:20][CH2:21]2)=[O:8])=[CH:9][CH:10]=1

Komponenten

3

Edukt 2

HCID 2389326-Bromonicotinic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Produkt 1

HCID 58484661(6-Bromopyridin-3-yl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneAusbeute 99,9 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 67 and using 6-bromonicotinic acid (808 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (765 mg) described in Preparation Example 47, the title compound (1.5 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 67
  3. customdescribed in Preparation Example 47

Quellen und Nachweise

ORD-Eintrag
ord-dd1fcf73389147b48bd2fc583ef2e1c4
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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