4-Bromo-2-fluorobenzoyl chloride → (4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyrazin-2-yl)piperazin-1-yl]methanone

HRID 1804055

Reaktionsgleichung

Reaktionsgleichung von HRID 1804055
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([F:11])[CH:3]=1.Cl.[CH3:13][C:14]1[C:15]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[N:16][CH:17]=[C:18]([CH3:20])[N:19]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:24]2[CH2:25][CH2:26][N:21]([C:15]3[C:14]([CH3:13])=[N:19][C:18]([CH3:20])=[CH:17][N:16]=3)[CH2:22][CH2:23]2)=[O:7])=[C:4]([F:11])[CH:3]=1

Komponenten

3

Edukt 2

HCID 27340264-Bromo-2-fluorobenzoyl chlorideHCID 67381341(3,5-Dimethylpyrazin-2-yl)piperazine hydrochloride

Produkt 1

HCID 58484696(4-Bromo-2-fluorophenyl)[4-(3,5-dimethylpyrazin-2-yl)piperazin-1-yl]methanoneAusbeute 69,9 %

Versuchsvorschrift

By reaction and treatment in the same manner as in Preparation Example 8 and using 4-bromo-2-fluorobenzoyl chloride (1.1 g) and 1-(3,5-dimethylpyrazin-2-yl)piperazine hydrochloride (915 mg) described in Preparation Example 59, the title compound (1.1 g) was obtained.

Aufarbeitung

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 8
  3. customdescribed in Preparation Example 59

Quellen und Nachweise

ORD-Eintrag
ord-4cd6e7e1f65a44afb88ec664acedf589
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354401B2

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