Water → HCID 57698624, Verbindung

HRID 1804546Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804546
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:11]=[C:12]([NH:16][C:17](=[O:22])[O:18][CH2:19][CH2:20]Cl)[CH:13]=[CH:14][CH:15]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].CC(C)([O-])C.[K+].O>O1CCCC1>[O:22]=[C:17]1[N:16]([C:12]2[CH:11]=[C:10]([CH:15]=[CH:14][CH:13]=2)[CH2:9][NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:20][CH2:19][O:18]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 23665647Potassium tert-butoxideHCID 57698618HCID 57698618, Verbindung

Produkt 1

HCID 57698624HCID 57698624, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1.20 g (3.65 mmol) 2-chloro-ethyl [3-(tert-butoxycarbonylamino-methyl)-phenyl]-carbamate and 0.850 g (7.58 mmol) potassium tert.butoxide are placed at 0° C. in 30 ml of tetrahydrofuran and the mixture is stirred for 3 hours at ambient temperature. Then the reaction mixture is added to water and extracted with dichloromethane. The organic phase is dried and evaporated to dryness. The residue is purified by chromatography.

Aufarbeitung

  1. extractionextracted with dichloromethane
  2. customThe organic phase is dried
  3. customevaporated to dryness
  4. customThe residue is purified by chromatography

Quellen und Nachweise

ORD-Eintrag
ord-20eaf5ef5883475ca85bc90d7be04b12
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354418B2

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