HCID 57637127, Verbindung → 5-(1-Methylethyl)-2-oxazoleethanamine
Reaktionsgleichung
[CH:1]([C:4]1[O:8][C:7]([CH2:9][CH2:10][NH:11]C(=O)OCC2C=CC=CC=2)=[N:6][CH:5]=1)([CH3:3])[CH3:2]>CO.[Pd]>[CH:1]([C:4]1[O:8][C:7]([CH2:9][CH2:10][NH2:11])=[N:6][CH:5]=1)([CH3:3])[CH3:2]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
6.50 g (22.54 mmol) benzyl [2-(5-isopropyl-oxazol-2-yl)-ethyl]-carbamate are placed in 130 ml of methanol, 3.50 g of 10% palladium/charcoal are added, then the mixture is hydrogenated for 5 hours at ambient temperature under a pressure of 14 psi. Then the catalyst is removed by suction filtering and the solution is evaporated down. The residue is extracted with dichloromethane and potassium carbonate solution, the organic phase is dried and evaporated to dryness.
Aufarbeitung
- customThen the catalyst is removed by suction
- filtrationfiltering
- customthe solution is evaporated down
- extractionThe residue is extracted with dichloromethane and potassium carbonate solution
- customthe organic phase is dried
- customevaporated to dryness
Quellen und Nachweise
- ORD-Eintrag
- ord-fdcbf61de0d443d18c2b64b49dd0f745
- Quelldatensatz
- uspto-grants-2013_01
- Patentnummer
- US08354418B2
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