HCID 67361944, Verbindung → HCID 59152645, Verbindung

HRID 1804769Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1804769
Cl.[CH3:2][C@@H:3]1[C@@H:8]([OH:9])[CH2:7][CH2:6][N:5]([CH2:10][CH2:11][C:12]23[CH2:19][CH2:18][CH:15]([CH2:16][CH2:17]2)[NH:14][O:13]3)[CH2:4]1>CO.[Pd]>[NH2:14][CH:15]1[CH2:16][CH2:17][C:12]([CH2:11][CH2:10][N:5]2[CH2:6][CH2:7][C@H:8]([OH:9])[C@@H:3]([CH3:2])[CH2:4]2)([OH:13])[CH2:19][CH2:18]1

Komponenten

4

Edukt 1

HCID 67361944HCID 67361944, Verbindung

Produkt 1

HCID 59152645HCID 59152645, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

10% Pd—C (240 mg) is placed into a round-bottom flask under an argon atmosphere and covered with methanol. A solution of (3S,4S)-3-Methyl-1-[2-(2-oxa-3-aza-bicyclo[2.2.2]oct-1-yl)-ethyl]-piperidin-4-ol (13) (584 mg, 2.3 mmol) in 20 ml of methanol is added and the mixture is hydrogenated for 2 h at room temperature. Then the mixture is filtrated over celite and evaporated under reduced pressure. The product was used in the next step without further purification.

Aufarbeitung

  1. filtrationThen the mixture is filtrated over celite
  2. customevaporated under reduced pressure
  3. customThe product was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-a4009fd2c65949e9b785aee14017b0ef
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354431B2

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