Methane → HCID 178518411, Verbindung

HRID 1805997Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1805997
ClC1N=[C:4](NC2C=C(C=CC=2)C(O)=O)[C:5]2[S:10][CH2:9][CH2:8][C:6]=2N=1.[NH2:21][C:22]([NH2:24])=[O:23].C.[OH-:26].[Na+]>>[N:21]1[C:6]2[CH:8]=[CH:9][S:10][C:5]=2[C:4]([OH:26])=[N:24][C:22]=1[OH:23]

Komponenten

5

Edukt 4

HCID 297MethaneHCID 1176UreaHCID 14798Sodium HydroxideHCID 576001073-(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)benzoic acid

Produkt 1

HCID 178518411HCID 178518411, VerbindungAusbeute 75 %

Versuchsvorschrift

10.0 g (64.0 mmol) of methylester 3-aminothiophene-2-carboxylate (I) and 19.0 g (31.60 mmol) of urea are mixed and melted for 2 hours at 200° C. After cooling, the reaction mixture is dissolved in 1 molar sodium hydroxide solution and decolorized with activated charcoal. It is filtered and the filtrate is cooled and acidified with 4M hydrochloric acid. The precipitate formed is suction filtered and dried. 8.03 g of product II (75%) is obtained as a powder.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationIt is filtered
  3. temperaturethe filtrate is cooled
  4. customThe precipitate formed
  5. filtrationfiltered
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-af2a06948cb2485f8b3359544a4488d2
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08354531B2

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