HCID 86638587, Verbindung → 2-(4-((4-(3-Aminophenylsulfonyl)piperazin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

HRID 1807811Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1807811
[F:1][C:2]([F:35])([F:34])[C:3]([C:9]1[CH:14]=[CH:13][C:12]([CH2:15][N:16]2[CH2:21][CH2:20][N:19]([S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([N+:31]([O-])=O)[CH:26]=3)(=[O:24])=[O:23])[CH2:18][CH2:17]2)=[CH:11][CH:10]=1)([OH:8])[C:4]([F:7])([F:6])[F:5]>[Pd].C(OCC)(=O)C>[NH2:31][C:27]1[CH:26]=[C:25]([S:22]([N:19]2[CH2:18][CH2:17][N:16]([CH2:15][C:12]3[CH:11]=[CH:10][C:9]([C:3]([OH:8])([C:2]([F:35])([F:34])[F:1])[C:4]([F:5])([F:6])[F:7])=[CH:14][CH:13]=3)[CH2:21][CH2:20]2)(=[O:23])=[O:24])[CH:30]=[CH:29][CH:28]=1

Komponenten

4

Edukt 1

HCID 86638587HCID 86638587, Verbindung

Produkt 1

HCID 866385882-(4-((4-(3-Aminophenylsulfonyl)piperazin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-olAusbeute 115,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

1,1,1,3,3,3-Hexafluoro-2-(4-((4-(3-nitrophenylsulfonyl)piperazin-1-yl)methyl)phenyl)propan-2-ol (1.660 mmol, 875.3 mg) and palladium on carbon were combined in ethyl acetate (20 mL). The reaction mixture was hydrogenated at 2 bar pressure for 1 hour. The reaction mixture was filtered through dicalite and concentrated under vacuum to afford the title compound (950.5 mg).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through dicalite
  2. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-c2449ea2a85044ffb759e48581fe0b31
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08357679B2

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