Oxalyl chloride → HCID 59752362, Verbindung

HRID 1808002Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1808002
[C:1]([O:4][C@H:5]1[CH2:10][C@H:9]([CH3:11])[CH2:8][CH2:7][C@H:6]1[C:12]([OH:14])=O)(=[O:3])[CH3:2].C(Cl)(=O)C([Cl:18])=O>ClCCl.CN(C)C=O>[C:1]([O:4][C@H:5]1[CH2:10][C@H:9]([CH3:11])[CH2:8][CH2:7][C@H:6]1[C:12]([Cl:18])=[O:14])(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 57457642(1R,2S,4R)-2-Acetoxy-4-methyl-cyclohexanecarboxylic acid

Produkt 1

HCID 59752362HCID 59752362, VerbindungAusbeute 100,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (1R,2S,4R)-2-Acetoxy-4-methyl-cyclohexanecarboxylic acid (109 mg, 0.54 mmol) in dichloromethane (2.7 ml) was added oxalyl chloride (545 ul, 1.09 mmol) followed by 1 drop of dimethylformamide. The reaction mixture was stirred for 4 h at room temperature. The solvents were then removed to obtain 119 mg (99%) of (1R*,2S*,4R*)-2-Acetoxy-4-methyl-cyclohexanecarboxylic acid chloride.

Aufarbeitung

  1. customThe solvents were then removed

Quellen und Nachweise

ORD-Eintrag
ord-64076f522c694225876d013d0659d4bb
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08357718B2

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