Ammonium Hydroxide → HCID 59361961, Verbindung

HRID 1808498Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1808498
C([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22](=[O:29])[C:23]3[CH:28]=[CH:27][CH:26]=[N:25][CH:24]=3)[CH:16]=1)[N:9]=[C:8]2[NH:30][C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][CH:39]=1)[N:36]([C:40]([O-])=[O:41])[N:35]=[CH:34]2)(=O)C.[NH4+].[OH-:44]>CO>[OH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22](=[O:29])[C:23]3[CH:28]=[CH:27][CH:26]=[N:25][CH:24]=3)[CH:16]=1)[N:9]=[C:8]2[NH:30][C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][CH:39]=1)[N:36]([C:40]([O:44][C:7]([CH3:12])([CH3:8])[CH3:6])=[O:41])[N:35]=[CH:34]2

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 866424105-(6-acetoxy-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Produkt 1

HCID 59361961HCID 59361961, VerbindungAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 5-(6-acetoxy-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate (0.374 g, 0.607 mmol) and 28% NH4OH (0.45 mL) in MeOH (50 mL) was stirred at RT for 24 h. The volatiles were removed in vacuo and the residue was washed with Et2O to give the product tert-butyl 5-(6-hydroxy-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate (0.318 g, 0.554 mmol, 91%).

Aufarbeitung

  1. customThe volatiles were removed in vacuo
  2. washthe residue was washed with Et2O

Quellen und Nachweise

ORD-Eintrag
ord-c9caac4491f84fe2a1eceead73f6ca05
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08357693B2

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