Eprosartan → HCID 86643031, Verbindung

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Crude eprosartan free base (50 gm, HPLC purity: 98.2%) is added to acetic acid (200 ml) under stirring at 25-30° C., the contents are heated to 80° C., to the resulting mass is added activated carbon (5 gm) and then stirred for 1 hour. The mass is filtered through a hyflow bed and the bed washed with hot acetic acid (50 ml). The filtrate is cooled to 25-30° C., methylene chloride (750 ml) is added drop wise to the mass and then stirred for 24 hours at 25-30° C. The mass is cooled to 0-5° C. and then stirred for 2 hours. The material is filtered, washed with methylene chloride (43 ml) and then dried to give 30 gm of pure eprosartan acetate (HPLC purity: 99.82%).

Herkunft & Nachweise