Benzene → 1-Methyl-1-phenyl-ethylisocyanate

HRID 1808734

Reaktionsgleichung

Reaktionsgleichung von HRID 1808734
C1C=CC=CC=1.[C:7]([NH2:16])([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:9])[CH3:8].C(N(CC)CC)C.[C:24](Cl)(Cl)=[O:25]>C(OCC)C.C1(C)C=CC=CC=1>[N:16]([C:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:9])[CH3:8])=[C:24]=[O:25]

Komponenten

7

Edukt 4

HCID 241BenzeneHCID 6371PhosgeneHCID 8471TriethylamineHCID 68509Cumylamine

Produkt 1

HCID 27694301-Methyl-1-phenyl-ethylisocyanate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a benzene (2 mL) solution of cumylamine (1.80 g, 13.3 mmol) and triethylamine (1.86 mL, 13.3 mmol) was added a 20% toluene solution of phosgene (17.5 mL, 33.3 mmol) dropwise. After completion, the reaction mixture was heated to 60° C. for 2 hours. It was then cooled to room temperature, charged with diethyl ether (20 mL), and filtered. Concentration of the filtrate in vacuo afforded the title compound. This crude product was used in the subsequent step without further purification.

Aufarbeitung

  1. temperatureIt was then cooled to room temperature
  2. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-fe3dccab2b714d998f38ddba15056b2c
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08361994B2

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