Sodium Hydroxide → 2-Bromo-5-ethylthiophene-3-carboxylic acid

HRID 1809081Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1809081
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([CH2:11][CH3:12])[S:8][C:7]=1[Br:13])=[O:5])C.[OH-].[Na+]>O>[Br:13][C:7]1[S:8][C:9]([CH2:11][CH3:12])=[CH:10][C:6]=1[C:4]([OH:5])=[O:3]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 12588560Ethyl2-bromo-5-ethylthiophene-3-carboxylate

Produkt 1

HCID 595425222-Bromo-5-ethylthiophene-3-carboxylic acidAusbeute 70,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

2-Bromo-5-ethyl-thiophene-3-carboxylic acid ethyl ester (0.7 g, 2.65 mmol) was dissolved in IMS (4 mL) and aqueous sodium hydroxide (1 M, 6 mL) was added. The reaction was heated to 140° C. using microwave irradiation for 10 minutes. Water (5 mL) was added and the white precipitate formed was isolated by filtration, washed with water and then dried under vacuum to give the title compound (0.44 g). 1H NMR (400 MHz, CHCl3-d): δ 7.1 (s, 1H), 2.7 (q, 2H), 1.25 (t, 3H).

Aufarbeitung

  1. custommicrowave irradiation for 10 minutes
  2. customthe white precipitate formed
  3. customwas isolated by filtration
  4. washwashed with water
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b8fa958165c549af9c83f0f96aa5bf86
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362008B2

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