Ammonium Hydroxide → 3-Cyanobenzene-1-sulfonamide

HRID 1809201

Reaktionsgleichung

Reaktionsgleichung von HRID 1809201
[NH4+:1].[OH-].[C:3]([C:5]1[CH:6]=[C:7]([S:11](Cl)(=[O:13])=[O:12])[CH:8]=[CH:9][CH:10]=1)#[N:4]>C(#N)C>[C:3]([C:5]1[CH:6]=[C:7]([S:11]([NH2:1])(=[O:13])=[O:12])[CH:8]=[CH:9][CH:10]=1)#[N:4]

Komponenten

4

Edukt 2

HCID 14923Ammonium HydroxideHCID 28013603-Cyanobenzene-1-sulfonyl chloride

Produkt 1

HCID 28087183-Cyanobenzene-1-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

NH4OH (22 mL, excess) can be added to a solution of 3-cyanobenzene-1-sulfonyl chloride (1.0 g, 4.97 mmol) in acetonitrile (22 mL) and the reaction stirred overnight at r.t. The reaction can be concentrated and the solid obtained washed with water to give 500 mg of product. The water phase can be extracted with AcOEt, dried with MgSO4 anh, filtered and evaporated to give 400 mg of product that can be combined with the solid obtained before (0.90 g, 99%).

Aufarbeitung

  1. customThe reaction
  2. concentrationcan be concentrated
  3. customthe solid obtained
  4. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-677cb9023bfe48a5bb62101c1c42c633
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362018B2

Verknüpfte Notizen

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