Tetrahydrofuran → 1-(5-Bromo-3-phenoxypyridin-2-yl)thiourea

HRID 1809547Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1809547
C([NH:9][C:10]([NH:12][C:13]1[C:18]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:17][C:16]([Br:26])=[CH:15][N:14]=1)=[S:11])(=O)C1C=CC=CC=1.C1COCC1.[OH-].[Na+]>O>[Br:26][C:16]1[CH:17]=[C:18]([O:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:13]([NH:12][C:10]([NH2:9])=[S:11])=[N:14][CH:15]=1

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 866410871-Benzoyl-3-(5-bromo-3-phenoxypyridin-2-yl)thiourea

Produkt 1

HCID 866314811-(5-Bromo-3-phenoxypyridin-2-yl)thioureaAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A 2 L flask was charged with 1-benzoyl-3-(5-bromo-3-phenoxypyridin-2-yl)thiourea (94.3 g, 220 mmol) and THF (900 mL). 2M NaOH (330 mL, 660 mmol) was added and the reaction was heated at reflux overnight. The reaction was cooled to ambient temperature and 300 mL water was added slowly and then the THF was removed in vacuo to afford an aqueous slurry which was filtered, washed with water and dried to give 1-(5-bromo-3-phenoxypyridin-2-yl)thiourea (66.35 g, 93% yield) as a light tan solid.

Aufarbeitung

  1. temperaturethe reaction was heated
  2. temperatureat reflux overnight
  3. customthe THF was removed in vacuo
  4. customto afford an aqueous slurry which
  5. filtrationwas filtered
  6. washwashed with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-2c4d19d8b65c41a587ecdfe6098d4560
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362037B2

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