(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester → (3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

HRID 1810310Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1810310
[CH3:1][O:2][C:3](=[O:23])[CH2:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([O:15]CC2C=CC=CC=2)[CH:6]=1>CCO.[Pd]>[CH3:1][O:2][C:3](=[O:23])[CH2:4][C:5]1[CH:10]=[C:9]([C:11]([F:12])([F:14])[F:13])[CH:8]=[C:7]([OH:15])[CH:6]=1

Komponenten

4

Edukt 1

HCID 58149337(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

Produkt 1

HCID 59644745(3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester (4.8 mmol) in EtOH was treated with 10% palladium on carbon (10% by weight), and stirred under a balloon of H2 at 60° C. overnight. The mixture was filtered to remove the palladium, and then concentrated to give the title compound.

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. customto remove the palladium
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d2a97f021b2046498b2ab5824da7238f
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362044B2

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