Dimethylformamide → 6-Chloro-2-fluoro-3-methylbenzamide

HRID 1811533Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1811533
[Cl:1][C:2]1[C:7]([C:8](O)=[O:9])=[C:6]([F:11])[C:5]([CH3:12])=[CH:4][CH:3]=1.C(Cl)Cl.C(Cl)(=O)C(Cl)=O.C[N:23](C=O)C>>[Cl:1][C:2]1[C:7]([C:8]([NH2:23])=[O:9])=[C:6]([F:11])[C:5]([CH3:12])=[CH:4][CH:3]=1

Komponenten

5

Edukt 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 27736696-Chloro-2-fluoro-3-methylbenzoic acid

Produkt 1

HCID 27736646-Chloro-2-fluoro-3-methylbenzamide

Versuchsvorschrift

To 6-chloro-2-fluoro-3-methylbenzoic acid (10 g, 53 mmol) is added CH2Cl2 (60 mL), DMF (0.5 mL) and oxalyl chloride (9.25 mL, 106 mmol). The reaction mixture is allowed to stir until it reaches homogeneity and is then concentrated in vacuo. The residue is poured onto a 50:50 mixture of ice and 36% ammonium hydroxide to yield 6-chloro-2-fluoro-3-methylbenzamide.

Aufarbeitung

  1. concentrationis then concentrated in vacuo
  2. additionThe residue is poured onto a 50:50 mixture of ice and 36% ammonium hydroxide

Quellen und Nachweise

ORD-Eintrag
ord-fe9138bc2818476d8569eb362bb0ab3b
Quelldatensatz
uspto-grants-2013_01
Patentnummer
US08362294B2

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