HCID 22505093, Verbindung → HCID 22505002, Verbindung

HRID 1814037Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1814037
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH:16]2[CH:14]([O:15]2)[CH2:13]1.[H][H]>[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH:16]2[CH:14]([O:15]2)[CH2:13]1

Komponenten

5

Edukt 2

HCID 22505093HCID 22505093, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 22505002HCID 22505002, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

10% Palladium on carbon (0.02 g) was added to 3-(2,6-difluoro-4-nitro-phenyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane (0.2 g, 0.83 mmol) dissolved in ethyl acetate (8.0 mL). The flask was charged with hydrogen gas and the mixture was stirred at room temperature for 3 h. The reaction mixture was filtered through celite and the solvent removed to get the title compound which was used directly in the next reaction.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe solvent removed

Quellen und Nachweise

ORD-Eintrag
ord-a86c43f291124a21a6ab0c32345eab09
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06875784B2

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