Water → 2-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

HRID 1814253Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1814253
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10][C:11]1[N:20]=[C:19]([NH:21][C@H:22]([CH3:25])[CH2:23][OH:24])[C:18]2[N:17]=[CH:16][C:15](=[O:26])[NH:14][C:13]=2[N:12]=1.[OH2:27].[OH:28]OS([O-])=O.[K+]>C(#N)C>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10]([C:11]1[N:20]=[C:19]([NH:21][C@H:22]([CH3:25])[CH2:23][OH:24])[C:18]2[N:17]=[CH:16][C:15](=[O:26])[NH:14][C:13]=2[N:12]=1)(=[O:28])=[O:27]

Komponenten

5

Edukt 3

HCID 962WaterHCID 23707502Potassium hydroxy sulfiteHCID 444550142-[[(2,3-Difluorophenyl)methyl]thio]4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

Produkt 1

HCID 688171932-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

2-[[(2,3-Difluorophenyl)methyl]thio]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone (0.38 g) was stirred in acetonitrile (150 ml) and water (150 ml) with oxone (3.79 g) for 18 hrs. Acetonitrile was removed in vacuo to leave an aqueous suspension. The solid was collected and dried in vacuo to afford the subtitled compound (0.30 g).

Aufarbeitung

  1. customAcetonitrile was removed in vacuo
  2. customto leave an aqueous suspension
  3. customThe solid was collected
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ff4ff4c13f9c4a9cb0fc8723f49233d1
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06875868B2

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