5-Benzyloxy-2-ethoxybenzonitrile → 2-Ethoxy-5-hydroxybenzonitrile

HRID 1814826Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1814826
C([O:8][C:9]1[CH:10]=[CH:11][C:12]([O:17][CH2:18][CH3:19])=[C:13]([CH:16]=1)[C:14]#[N:15])C1C=CC=CC=1>CO.[Pd]>[CH2:18]([O:17][C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[CH:16][C:13]=1[C:14]#[N:15])[CH3:19]

Komponenten

4

Edukt 1

HCID 219731695-Benzyloxy-2-ethoxybenzonitrile

Produkt 1

HCID 219731772-Ethoxy-5-hydroxybenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

40.02 g of 5-benzyloxy-2-ethoxybenzonitrile (158 mmol) (example 32A) and 5% Pd/C (4.0 g) are initially charged in 1 l of methanol. The mixture is then hydrogenated under an atmosphere of hydrogen (1 atm) for about 4 h. The mixture is filtered through kieselguhr and evaporated and the crystalline residue is dried under reduced pressure.

Aufarbeitung

  1. filtrationThe mixture is filtered through kieselguhr
  2. customevaporated
  3. customthe crystalline residue is dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9fb0b2482bc2416c95f7ad4b8a4d785b
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06878708B2

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