Hydrochloric Acid → HCID 68984012, Verbindung

HRID 1815505Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1815505
[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])[CH:7]=[CH:6][C:3]=1[CH:4]=O.C(O)(=O)[CH2:21][C:22]([OH:24])=[O:23].N1CCCCC1.Cl>N1C=CC=CC=1>[Cl:1][C:2]1[C:9]([Cl:10])=[C:8]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])[CH:7]=[CH:6][C:3]=1[CH:4]=[CH:21][C:22]([OH:24])=[O:23]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 867Malonic AcidHCID 8082PiperidineHCID 11088283HCID 11088283, Verbindung

Produkt 1

HCID 68984012HCID 68984012, VerbindungAusbeute 75,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A mixture of 2,3-dichloro-4-(2-methoxyphenylthio)-benzaldehyde (2.03 g), 1.44 g malonic acid, 5 mL pyridine, and 0.100 g piperidine was heated to 115 degrees for 1.5 hours. The mixture was cooled, and ice and HCl were added. The resulting solid was: filtered, washed with water and dissolved in tetrahydrofuran. This solution was dried over sodium sulfate, the solvent removed and ether added to give 1.733 g of product, m.p. 187-188 C.

Aufarbeitung

  1. temperaturewas heated to 115 degrees for 1.5 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. washwashed with water
  5. dissolutiondissolved in tetrahydrofuran
  6. dry with materialThis solution was dried over sodium sulfate
  7. customthe solvent removed
  8. additionether added

Quellen und Nachweise

ORD-Eintrag
ord-e7c4077b4bc948b6840d079a7747a91a
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06878700B1

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