Methylamine → 6H-oxazolo[4,5-e]indole

HRID 18158

Reaktionsgleichung

Reaktionsgleichung von HRID 18158
[CH3:1][NH2:2].[OH:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[CH:7]2>CN(C=O)C.O=[Mn]=O>[N:2]1[C:5]2=[C:6]3[C:10](=[CH:11][CH:12]=[C:4]2[O:3][CH:1]=1)[NH:9][CH:8]=[CH:7]3

Komponenten

5

Edukt 2

HCID 6329MethylamineHCID 160545-Hydroxyindole

Produkt 1

HCID 113326096H-oxazolo[4,5-e]indole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

0.5 mmol of methylamine and 4.13 mmol of MnO2 are added to a solution of 0.4 mmol of 5-hydroxy-1H-indole in 3 ml of DMF, and the mixture is stirred at room temperature for 18 hours. The suspension is filtered through Celite and subjected to conventional work-up, giving 6H-oxazolo[4,5-e]indole; ESI 159.

Aufarbeitung

  1. filtrationThe suspension is filtered through Celite

Quellen und Nachweise

ORD-Eintrag
ord-48e2ebd3ce31455ea6dd59c9383f0a06
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741343B2

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