Water → 1-Acetyl-4-[4-(6-bromohexyloxy)phenyl]piperazine

A mixture of 1-acetyl-4-(4-hydroxyphenyl)piperazine (5.00 g) in N,N-dimethylformamide (50 ml) was treated with 1,6-dibromohexane (10.5 ml) and potassium carbonate (4.71 g), and the mixture was stirred for 18 hours at ambient temperature. To the reaction mixture was added water (200 ml), and the resulting precipitate was collected by filtration, washed with water and n-hexane successively and dried under reduced pressure to give crude 1-acetyl-4-[4-(6-bromohexyloxy)phenyl]piperazine (10.52 g), that was used in the next reaction directly.

1. filtrationthe resulting precipitate was collected by filtration
2. washwashed with water and n-hexane successively
3. customdried under reduced pressure

ORD-Eintrag

ord-bafeeaf2ccd6483ebb41454ba9380c1a

Quelldatensatz

uspto-grants-2005_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06884868B1