2,5-Dimethoxytetrahydrofuran → 1-(2-methylpropyl)-8-(1-pyrrolyl)-1H-imidazo[4,5-c]quinolin-4-amine

HRID 1818219

Reaktionsgleichung

Reaktionsgleichung von HRID 1818219
CO[CH:3]1[CH2:7][CH2:6][CH:5](OC)O1.[NH2:10][C:11]1[CH:20]=[CH:19][C:18]2[N:17]=[C:16]([NH2:21])[C:15]3[N:22]=[CH:23][N:24]([CH2:25][CH:26]([CH3:28])[CH3:27])[C:14]=3[C:13]=2[CH:12]=1>C(O)(=O)C>[CH3:27][CH:26]([CH3:28])[CH2:25][N:24]1[C:14]2[C:13]3[CH:12]=[C:11]([N:10]4[CH:3]=[CH:7][CH:6]=[CH:5]4)[CH:20]=[CH:19][C:18]=3[N:17]=[C:16]([NH2:21])[C:15]=2[N:22]=[CH:23]1

Komponenten

4

Edukt 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 111961298-amino-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine

Produkt 1

HCID 219841381-(2-methylpropyl)-8-(1-pyrrolyl)-1H-imidazo[4,5-c]quinolin-4-amineAusbeute 57,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2,5-Dimethoxytetrahydrofuran (1.6 mL of 95%, 12 mmol) was added to a suspension of 8-amino-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine (3.0 g, 12 mmol) in acetic acid (60 mL), and the reaction was heated at reflux for one hour. The resulting dark brown solution was concentrated under reduced pressure, and the residue was mixed with water. The resulting mixture was made basic with the addition of ammonium hydroxide and stirred for 30 minutes. The resulting precipitate was isolated by filtration, washed with water, dried, and recrystallized from ethanol (100 mL). The crystals were collected in three crops. The first crop was dried for a day in a vacuum oven at 100° C. to provide 2.1 g of 1-(2-methylpropyl)-8-(1-pyrrolyl)-1H-imidazo[4,5-c]quinolin-4-amine as a solid, mp 227.5-231.5° C.

Aufarbeitung

  1. temperaturethe reaction was heated
  2. temperatureat reflux for one hour
  3. concentrationThe resulting dark brown solution was concentrated under reduced pressure
  4. additionthe residue was mixed with water
  5. additionThe resulting mixture was made basic with the addition of ammonium hydroxide
  6. customThe resulting precipitate was isolated by filtration
  7. washwashed with water
  8. customdried
  9. customrecrystallized from ethanol (100 mL)
  10. customThe crystals were collected in three crops
  11. customThe first crop was dried for a day in a vacuum oven at 100° C.

Quellen und Nachweise

ORD-Eintrag
ord-1d98d71f9cb045a494b86568b63fa1f8
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07598382B2

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