Hydrochloric Acid → 2,6-Dimethyl-4-nitroaniline

HRID 1820117

Reaktionsgleichung

Reaktionsgleichung von HRID 1820117
Cl.[CH3:2][C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[C:5]([CH3:12])[C:4]=1[NH:13]C(=O)C.C(=O)([O-])[O-].[Na+].[Na+]>O>[CH3:2][C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[C:5]([CH3:12])[C:4]=1[NH2:13]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 50851089N-(2,6-dimethyl-4-nitrophenyl)acetamide

Produkt 1

HCID 281592,6-Dimethyl-4-nitroanilineAusbeute 97,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

Concentrated hydrochloric acid (17.5 mL) was added to N-(2,6-dimethyl-4-nitro-phenyl)-acetamide (5.05 g) and heated to 140° C. for 30 minutes in a sealed microwave process vial. The reaction mixture was neutralized with solid sodium carbonate in water and the precipitated product was collected by filtration and washed with water (100 mL) to furnish 3.93 g (97% yield) of the title compound as a yellow solid. 1H NMR (500 MHz, DMSO-d6): 2.15 (s, 6H), 6.15 (b, 2H), 7.79 (s, 2H).

Aufarbeitung

  1. filtrationthe precipitated product was collected by filtration
  2. washwashed with water (100 mL)

Quellen und Nachweise

ORD-Eintrag
ord-6495e0fce7c44ab6b87b955008f683f2
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07601870B2

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