Water → Guanine

HRID 1820617Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1820617
[CH:1]1[NH:2][C:3]2[N:9]=[C:8]([NH2:10])[N:7]=[C:6](Cl)[C:4]=2[N:5]=1.C(N(CC)CC)C.C[O:20]C1C=C(C)C(S)=CC=1.O>CO>[NH:7]1[C:6](=[O:20])[C:4]2[NH:5][CH:1]=[N:2][C:3]=2[N:9]=[C:8]1[NH2:10]

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 27595964-Methoxy-2-methylbenzenethiolHCID 1785084356-chloro-1H-purin-2-amine

Produkt 1

HCID 135398634Guanine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

6-Chloroguanine derivative prepared in Preparation 6 (4.86 g) was dissolved in 85 Ml of methanol and 1.4 g of triethylamine and 2.9 g of 4-methoxythiocresol were added. The reaction mixture was reacted under reflux condition for 24 hours. The reaction was stopped by adding 20 ml of water, and the methanol was removed by distillation under reduced pressure. The reaction mixture was extracted with dichloromethane and purified by silica gel column to give a compound wherein 6-position of guanine was substituted by 4-methoxyphenylthio group.

Aufarbeitung

  1. additionwere added
  2. customThe reaction mixture was reacted
  3. temperatureunder reflux condition for 24 hours
  4. customthe methanol was removed by distillation under reduced pressure
  5. extractionThe reaction mixture was extracted with dichloromethane
  6. custompurified by silica gel column

Quellen und Nachweise

ORD-Eintrag
ord-73eaabc63dc848c5bb674f2004129df8
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07605147B2

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