Formic Acid → 6-Bromo-4-azabenzimidazole
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH:10](O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[CH:10][NH:8][C:5]2=[N:6][CH:7]=1Komponenten
3
Versuchsvorschrift
5-Bromo-2,3-diaminopyridine (1.69 g, 8.99 mmole) was taken up in 96% formic acid (50 mL) and heated to reflux. After 18 hr the mixture was cooled to RT and concentrated. The residue was taken up in H2O and the pH was adjusted to 7 with 2.0 M NaOH. The title compound (1.54 g, 87%) was collected as a solid by filtration, washed with H2O, and dried in vacuo: MS (ES) m/e 198/200 (M+H)+.
Aufarbeitung
- temperatureheated to reflux
- concentrationconcentrated
- filtrationThe title compound (1.54 g, 87%) was collected as a solid by filtration
- washwashed with H2O
- customdried in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-927531f2479049d7b1a9c998d4269d4f
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07741339B2
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