Formic Acid → 6-Bromo-4H-imidazo[4,5-b]pyridine

HRID 18216

Reaktionsgleichung

Reaktionsgleichung von HRID 18216
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH:10](O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[CH:10][NH:8][C:5]2=[N:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 284Formic AcidHCID 6911565-Bromopyridine-2,3-diamine

Produkt 1

HCID 9115786-Bromo-4H-imidazo[4,5-b]pyridine

Versuchsvorschrift

5-Bromo-2,3-diaminopyridine (1.69 g, 8.99 mmole) was taken up in 96% formic acid (50 mL) and heated to reflux. After 18 hr the mixture was cooled to RT and concentrated. The residue was taken up in H2O and the pH was adjusted to 7 with 2.0 M NaOH. The title compound (1.54 g, 87%) was collected as a solid by filtration, washed with H2O, and dried in vacuo: MS (ES) m/e 198/200 (M+H)+.

Aufarbeitung

  1. temperatureheated to reflux
  2. concentrationconcentrated
  3. filtrationThe title compound (1.54 g, 87%) was collected as a solid by filtration
  4. washwashed with H2O
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-927531f2479049d7b1a9c998d4269d4f
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741339B2

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