Itaconic acid → HCID 21920059, Verbindung
Reaktionsgleichung
[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][O:7][C:8]2[N:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:17]([OH:25])(=[O:24])[C:18]([CH2:20][C:21](O)=[O:22])=[CH2:19]>>[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][O:7][C:8]2[N:13]=[CH:12][C:11]([N:14]3[C:21](=[O:22])[CH2:20][CH:18]([C:17]([OH:25])=[O:24])[CH2:19]3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
In an analogous manner to that described in Example 36c), the reaction of 6-(4-fluoro-benzyloxy)-pyridin-3-ylamine with itaconic acid yields the crude (RS)-1-[6-(4-fluoro-benzyloxy)-pyridin-3-yl]-5-oxo-pyrrolidine-3-carboxylic acid as a green solid (yield 47% of theory).
Quellen und Nachweise
- ORD-Eintrag
- ord-16ed2fe5c4a84c3d9b44a9f0852e6947
- Quelldatensatz
- uspto-grants-2006_05
- Patentnummer
- US07037935B2