4-Chlorobenzoyl chloride → 3-(3-Bromo-thiophen-2-yl)-5-(4-chloro-phenyl)-[1,2,4]-oxadiazole
Reaktionsgleichung
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[Br:11][C:12]1[CH:16]=[CH:15][S:14][C:13]=1[C:17](=[N:19]O)[NH2:18]>>[Br:11][C:12]1[CH:16]=[CH:15][S:14][C:13]=1[C:17]1[N:19]=[C:6]([C:5]2[CH:9]=[CH:10][C:2]([Cl:1])=[CH:3][CH:4]=2)[O:7][N:18]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 4-chloro-benzoyl chloride (60 μL, 0.47 mmol) and 3-bromo-thiophene-2-amidoxime (102 mg, 0.461 mmol) similar to Example 36c, and yielded 80 mg (51%) of white solid. 1H NMR (CDCl3): 8.15 (dd, J=9.09, 2.06 Hz, 2H), 7.54 (dd, J=8.51, 2.20 Hz, 2H), 7.50 (d, J=5.22 Hz, 1H), 7.18 (d, J=5.22 Hz, 1H).
Quellen und Nachweise
- ORD-Eintrag
- ord-e980165ce8d14c42ac2a291299a3bcc2
- Quelldatensatz
- uspto-grants-2006_05