2-[4-(3-Chloro-propoxy)-phenyl]-imidazo[1,2-a]pyridine → 2-[4-(3-Chloro-propoxy)-phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

HRID 1824494

Reaktionsgleichung

Reaktionsgleichung von HRID 1824494
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]3[CH:20]=2)=[CH:8][CH:7]=1>C(O)C.CO.[Pt](=O)=O>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[CH2:19][CH2:18][CH2:17][CH2:16][N:15]3[CH:20]=2)=[CH:8][CH:7]=1

Komponenten

5

Edukt 1

HCID 140970942-[4-(3-Chloro-propoxy)-phenyl]-imidazo[1,2-a]pyridine

Produkt 1

HCID 220156272-[4-(3-Chloro-propoxy)-phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridineAusbeute 96,4 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 345198Adams' catalystKatalysatorHCID 702EthanolLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a Parr bottle charged with a mixture of platinum (IV) oxide (30 mg) in ethanol (3 mL) was added a solution of the product of Step A (90 mg) in methanol (6 ml). The mixture was hydrogenated at 40 psi for 4 hours and filtered through a Celite pad which was rinsed with several additional milliliters of methanol and ethanol. The filtrate was collected and evaporated in vacuo to yield the title compound (88 mg) which was used without further purification.

Aufarbeitung

  1. filtrationfiltered through a Celite pad which
  2. washwas rinsed with several additional milliliters of methanol and ethanol
  3. customThe filtrate was collected
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7c9b26862e35403089f0e0be3a0f421e
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07041827B2

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