Water → 5-Bromo-6-methoxy-2-methylthioquinoline

HRID 1825859

Reaktionsgleichung

Reaktionsgleichung von HRID 1825859
[Br:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([S:14]([CH3:17])(=O)=O)=[N:7]2.O>CN(C=O)C>[Br:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([S:14][CH3:17])=[N:7]2

Komponenten

4

Edukt 2

HCID 962WaterHCID 221397325-Bromo-2-methanesulfonyl-6-methoxy-quinoline

Produkt 1

HCID 221396965-Bromo-6-methoxy-2-methylthioquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The 5-bromo-2-methanesulfonyl-6-methoxy-quinoline was dissolved in 20 mL DMF and treated with 3 eq NaSCH3. After stirring 1 hour at room temperature the mixture was poured into water and extracted with ether. The crystalline product, 5-bromo-6-methoxy-2-methylsulfanyl-quinoline, was isolated in quantitative yield.

Aufarbeitung

  1. additiontreated with 3 eq NaSCH3
  2. extractionextracted with ether

Quellen und Nachweise

ORD-Eintrag
ord-0b7c09262ddf44c49e91fbe659baecaf
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07049325B2

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