Ethyl indole-2-carboxylate → 7-Fluoro-1-methylindole-3-carboxaldehyde

HRID 18260

Reaktionsgleichung

Reaktionsgleichung von HRID 18260
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[CH:11]=[O:12].N1C2C(=CC=CC=2)C=[C:14]1C(OCC)=O>>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH3:14])[CH:8]=[C:7]2[CH:11]=[O:12]

Komponenten

3

Edukt 2

HCID 73125Ethyl indole-2-carboxylateHCID 221391207-Fluoro-1H-indole-3-carbaldehyde

Produkt 1

HCID 221390377-Fluoro-1-methylindole-3-carboxaldehydeAusbeute 43 %

Versuchsvorschrift

According to the procedure of Preparation 9 (a), except substituting 7-fluoro-1H-indole-3-carboxaldehyde (0.5 g, 3.1 mmole) for the ethyl indole-2-carboxylate, the title compound (0.23 g, 43%) was prepared as a viscous oil: MS (ES) m/e 178 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-ff2ee5770f174403ba474c3949bbf8f4
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741339B2

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