HCID 178418361, Verbindung → HCID 178481603, Verbindung

HRID 1826518Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1826518
[OH:1][C:2]1[N:7]([CH3:8])[C:6](=[O:9])[C:5]([N+:10]([O-])=O)=[C:4]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[N:3]=1.[H][H]>CO.[OH-].[Na+].[Pd]>[NH2:10][C:5]1[C:6](=[O:9])[N:7]([CH3:8])[C:2]([OH:1])=[N:3][C:4]=1[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1

Komponenten

6

Edukt 2

HCID 178418361HCID 178418361, VerbindungHCID 178481604HCID 178481604, Verbindung

Produkt 1

HCID 178481603HCID 178481603, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

To a solution of 2-hydroxy-3-methyl-5-nitro-6-pyridin-4-yl-3H-pyrimidin-4-one (22.6 mmol) in 200 mL methanol and 75 mL 1N sodium hydroxide was added 50 mg Pd/C and stirred overnight under a balloon filled with hydrogen. The solvents were removed under vacuum. The solids were suspended in water and acidified to pH 5 with SN HCl. The solid was collected by filtration. M+1=219.

Aufarbeitung

  1. customThe solvents were removed under vacuum
  2. filtrationThe solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-13b248c7849b425eb622d8add81b8ab4
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07049318B2

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