Tetrahydrofuran → Tert-butyl (piperidin-4-ylmethyl)carbamate

HRID 1827180Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1827180
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.C1COCC1>[Pd].CO>[C:22]([O:21][C:19](=[O:20])[NH:18][CH2:17][CH:14]1[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1)([CH3:25])([CH3:23])[CH3:24]

Komponenten

5

Edukt 2

HCID 8028TetrahydrofuranHCID 23577280Benzyl 4-{[(tert-butoxycarbonyl)amino]methyl}piperidine-1-carboxylate

Produkt 1

HCID 723429Tert-butyl (piperidin-4-ylmethyl)carbamate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 28 g of 4-(tert-butoxycarbonylamino-methyl)-piperidine-1-carboxylic acid benzyl ester, 1 g of 10% palladium on carbon, 100 mL of THF and 200 mL of methanol was stirred under an atmosphere of hydrogen for 2 days. The mixture was filtered concentrated under reduced pressure. Drying under reduced pressure gave a white solid:

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated under reduced pressure
  3. customDrying under reduced pressure
  4. customgave a white solid

Quellen und Nachweise

ORD-Eintrag
ord-1788f293f7604426b11ff8c369ee5902
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07053089B2

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