HCID 22136507, Verbindung → HCID 69353514, Verbindung

HRID 1827485Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1827485
[C:1]([Si:5]([CH3:13])([CH3:12])[O:6][CH2:7][C:8]#[C:9][CH2:10][NH2:11])([CH3:4])([CH3:3])[CH3:2].[CH3:14][C:15]1[CH:20]=[C:19]([CH3:21])[N:18]=[C:17]([CH:22]=[CH:23][C:24]2[C:32]3[C:27](=[CH:28][C:29]([NH:33][C:34]4[CH:42]=[CH:41][CH:40]=[CH:39][C:35]=4[C:36](O)=[O:37])=[CH:30][CH:31]=3)[N:26]([CH:43]3[CH2:48][CH2:47][CH2:46][CH2:45][O:44]3)[N:25]=2)[CH:16]=1>O>[C:1]([Si:5]([CH3:13])([CH3:12])[O:6][CH2:7][C:8]#[C:9][CH2:10][NH:11][C:36](=[O:37])[C:35]1[CH:39]=[CH:40][CH:41]=[CH:42][C:34]=1[NH:33][C:29]1[CH:28]=[C:27]2[C:32]([C:24]([CH:23]=[CH:22][C:17]3[CH:16]=[C:15]([CH3:14])[CH:20]=[C:19]([CH3:21])[N:18]=3)=[N:25][N:26]2[CH:43]2[CH2:48][CH2:47][CH2:46][CH2:45][O:44]2)=[CH:31][CH:30]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 22136507HCID 22136507, VerbindungHCID 69353735HCID 69353735, Verbindung

Produkt 1

HCID 69353514HCID 69353514, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Prepared in a similar manner to that described for Example 33(a) step (v), in U.S. Pat. No. 6,531,491, issued Mar. 11, 2003, herein incorporated by reference in its entirety for all purposes, except using 4-(tert-Butyl-dimethyl-silanyloxy)-but-2-ynylamine and 2-[3-[2-(4,6-Dimethyl-pyridin-2-yl)-vinyl]-1-(tetrahydro-pyran-2-yl)-1H-indazol-6-ylamino]-benzoic acid. 1H NMR (DMSO-d6) δ 9.56 (1H, s), 9.01 (1H, t, J=5.7 Hz), 8.06 (1H, d, J=8.7 Hz), 7.81 (1H, d, J=16.4 Hz), 7.66 (1H, d, J=7.5 Hz), 7.41 (4H, m), 7.32 (1H, s), 7.09 (1H, dd, J=1.8, 8.7 Hz), 6.98 (1H, s), 6.89 (1H, t, J=8.0 Hz), 5.79 (1H, dd, J=2.4, 9.2 Hz), 4.28 (2H, s), 4.09 (2H, m), 3.86(1H,m), 3.72 (1H, m), 2.46 (3H, s), 2.42 (1H, m), 2.30 (3H, s), 2.08 (2H, m), 1.74 (1H, m), 1.57 (2H, m), 0.80 (9H, s), 0.03 (6H, s). Anal. Calcd for C38H47N5O3Si. 0.7 H2O: C, 68.89; H, 7.36; N, 10.57. Found: C, 68.99; H, 7.36; N, 10.21.

Aufarbeitung

  1. customPrepared in a similar manner to that

Quellen und Nachweise

ORD-Eintrag
ord-f979418135414112b2dd9cf0c23e8153
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07053107B2

Notizen zur Reaktion

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