1,3-Dimethyl-1H-pyrazole-5-carbonitrile → (1,3-Dimethyl-1H-pyrazol-5-yl)methanamine

HRID 1827504Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1827504
[CH3:1][N:2]1[C:6]([C:7]#[N:8])=[CH:5][C:4]([CH3:9])=[N:3]1>[Pd].C(O)C>[CH3:1][N:2]1[C:6]([CH2:7][NH2:8])=[CH:5][C:4]([CH3:9])=[N:3]1

Komponenten

4

Edukt 1

HCID 27362971,3-Dimethyl-1H-pyrazole-5-carbonitrile

Produkt 1

HCID 1257670(1,3-Dimethyl-1H-pyrazol-5-yl)methanamineAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of 2,5-Dimethyl-2H-pyrazole-3-carbonitrile (654 mg, 5.4 mmol) and 10% palladium on carbon (200 mg) in ethanol (15 mL) was shaken in a Parr hydrogenation apparatus under 45 psi H2 for 17 hr. The mixture was filtered through celite and the filtrate was concentrated under reduced pressure to give 608 mg of an oil which was used without any further purification. 1H NMR (CDCl3) δ 5.91 (1H, s), 3.81, 3.73 (2H,2s), 3.75 (3H, s), 2.21 (3H, s).

Aufarbeitung

  1. filtrationThe mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5774c3dfd7d147e1ba0495209d37260a
Quelldatensatz
uspto-grants-2006_05
Patentnummer
US07053107B2

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