Anisole → HCID 178439804, Verbindung

HRID 1828513Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1828513
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:41]=[CH:40][N:14]3[C:15](=[O:39])[C:16]([C:25]4[N:29](CC5C=CC(OC)=CC=5)[N:28]=[N:27][N:26]=4)=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:41]=[CH:40][N:14]3[C:15](=[O:39])[C:16]([C:25]4[NH:29][N:28]=[N:27][N:26]=4)=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 7519AnisoleHCID 696031968-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl)-2-morpholino-3-(1-p-methoxybenzyl-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one2×

Produkt 1

HCID 178439804HCID 178439804, VerbindungAusbeute 88,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

The 8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-morpholino-3-(1-p-methoxybenzyl-1,2,3,4-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one (10 mg) obtained in (C) was dissolved in trifluoroacetic acid (1 ml) and added with anisole (50 ml), and then stirred at room temperature for 4 hours. After the solvent was evaporated, the residue was purified by silica gel column chromatography to obtain the title compound (7 mg) as yellow powder.

Aufarbeitung

  1. customAfter the solvent was evaporated
  2. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-6a300be324554dae880183e637b2b981
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07056917B2

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