(2-Azido-3-fluoro-propyl)benzene → 1-Fluoro-3-phenylpropan-2-amine

HRID 1829783Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1829783
[N:1]([CH:4]([CH2:12][F:13])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[N+]=[N-]>CO.[Pd]>[F:13][CH2:12][CH:4]([NH2:1])[CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Komponenten

4

Edukt 1

HCID 22054864(2-Azido-3-fluoro-propyl)benzene

Produkt 1

HCID 50645991-Fluoro-3-phenylpropan-2-amineAusbeute 74,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

To a solution of (2-azido-3-fluoro-propyl)benzene (0.6 g) in MeOH (50 mL) was added 10% Pd/C catalyst and the suspension was hydrogenated for 2 h at 3 atmospheres pressure. The filtered reaction mixture and MeOH washings were concentrated to an oil which was chromatographed over silica gel with an ammoniated mixture of MeOH/ether (1:9) to give 0.38 g of the title compound. MS ES (M++H)=154.

Aufarbeitung

  1. concentrationwere concentrated to an oil which
  2. customwas chromatographed over silica gel with an ammoniated mixture of MeOH/ether (1:9)

Quellen und Nachweise

ORD-Eintrag
ord-6a375726eb504ddab1e32467e919d902
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07064143B1

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