Potassium Fluoride → HCID 22049881, Verbindung

HRID 1830930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1830930
[CH:1]1([C:4]2[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.[F-:14].[K+]>CC(C)=O.O.CCOC(C)=O>[CH:1]1([C:4]2[CH:9]=[CH:8][C:7]([S:10]([F:14])(=[O:12])=[O:11])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1

Komponenten

6

Edukt 2

HCID 522689Potassium FluorideHCID 220498824-Cyclopropylbenzenesulphonyl chloride

Produkt 1

HCID 22049881HCID 22049881, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 180AcetoneLösungsmittelHCID 962WaterLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Crude compound 45 (13.3 g) was dissolved in 200 mL of acetone and 60 mL of water. Potassium fluoride (7.12 g, 122 mmol) was added and the reaction mixture was stirred overnight at rt. The reaction mixture was diluted with EtOAc and washed with water. The organic layer was dried with Na2SO4, filtered, and concentrated to dryness to give 9.80 g (97%) of crude p-cyclopropyl benzenesulfonyl fluoride (Compound 46).

Aufarbeitung

  1. washwashed with water
  2. dry with materialThe organic layer was dried with Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-742ff3e8909c4e08b0bb6e3d82f1effe
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067539B2

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