4-Chlorobenzylpiperazine → 4-(4-Chlorobenzyl)piperazine-1-carboxylic Acid 4-(4-trifluoromethylphenoxy)phenyl Ester

HRID 1831261Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1831261
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)=[CH:7][CH:6]=1)=[O:3].[Cl:22][C:23]1[CH:35]=[CH:34][C:26]([CH2:27][N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[CH:25][CH:24]=1.[K+].[Br-]>O>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:31]3[CH2:30][CH2:29][N:28]([CH2:27][C:26]4[CH:34]=[CH:35][C:23]([Cl:22])=[CH:24][CH:25]=4)[CH2:33][CH2:32]3)=[O:3])=[CH:6][CH:7]=2)=[CH:13][CH:14]=1

Komponenten

5

Edukt 3

HCID 1348264-ChlorobenzylpiperazineHCID 253877Potassium BromideHCID 220478044-(4-Trifluoromethylphenoxy)phenyl chloroformate

Produkt 1

HCID 574558284-(4-Chlorobenzyl)piperazine-1-carboxylic Acid 4-(4-trifluoromethylphenoxy)phenyl Ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The hydrochloride of the title compound was prepared from 4-(4-trifluoromethylphenoxy)phenyl chloroformate and 1-(4-chlorobenzyl)piperazine, yield 86%. White crystals, m.p. 232–234° C.; 1H NMR (DMSO-d6): δ 11.92 (br s, 1H), 3 AB-systems: 7.83–7.62 (t-like, 4H) and 7.62–7.48 (d-like, 2H), and 7.32–7.07 (m, 6H); 4.51–3.95 (br s at 4.37 ppm overlapping with br signal at 4.2 ppm, 4H), 3.95–2.95 (br m, 9H: 6H+water); IR (KBr): ν 1717 (C═O) cm−1.

Quellen und Nachweise

ORD-Eintrag
ord-7546e05de0da4570a3bc7dc30803dea5
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067517B2

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