Sodium Dithionite → 4-(2-chloro-4-methoxy-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][N:13]=[C:12]([NH:16][CH:17]([CH:20]2[CH2:22][CH2:21]2)[CH2:18][CH3:19])[C:11]=1[N+:23]([O-])=O.[O-]S(S([O-])=O)=O.[Na+].[Na+]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][N:13]=[C:12]([NH:16][CH:17]([CH:20]2[CH2:21][CH2:22]2)[CH2:18][CH3:19])[C:11]=1[NH2:23]Komponenten
3
Versuchsvorschrift
[4-(2-Chloro-4-methoxy-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-propyl)-amine (0.56 g, 1.55 mmol) and Na2S2O4 (2.17 g, 12.5 mmol) were treated substantially as described in Part E of Example 9 to give 0.49 g (96%) of crude 4-(2-chloro-4-methoxy-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine: MS (AP) m/z 331.8 [(M+H)+, 100].