Dichloroacetic Acid → HCID 54724182, Verbindung

HRID 1832016Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1832016
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]1=[O:13].[I:17]N1C(=O)CCC1=O.ClC(Cl)C(O)=O>C(#N)C>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([I:17])[C:7]1=[O:13]

Komponenten

5

Edukt 3

HCID 6597Dichloroacetic AcidHCID 120273N-IodosuccinimideHCID 54724162HCID 54724162, Verbindung

Produkt 1

HCID 54724182HCID 54724182, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a mixture of 1-(3-fluorobenzyl)-4-hydroxypyridin-2(1H)-one (1.1 g, 5 mmol) in acetonitrile (15 mL) was added N-iodosuccinimide (1.1 g, 5.5 mmol) along with a ca. amount of dichloroacetic acid (0.1 mL). The reaction mixture stirred at room temperature for 1 hour under nitrogen. The mixture was chilled in an ice bath and filtered cold with fresh MeCl2. The beige solid was dried to afford the desired iodinated intermediate (1.21 g, 69%). ES-LRMS m/z 346.

Aufarbeitung

  1. temperatureThe mixture was chilled in an ice bath
  2. filtrationfiltered cold with fresh MeCl2
  3. customThe beige solid was dried
  4. customto afford the

Quellen und Nachweise

ORD-Eintrag
ord-ee33e594a3b545c2a5d89d6c8aeb8ae8
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067540B2

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