Tetrabutylammonium Fluoride → HCID 135405285, Verbindung

HRID 1835638Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1835638
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[CH2:19]([O:26][C@@H:27]1[C@@:31]2([CH2:51][O:52][C@H:28]1[C@H:29]([N:53]1[C:68]3[N:67]=[C:60]([NH:61][C:62](=[O:66])[CH:63]([CH3:65])[CH3:64])[NH:59][C:57](=[O:58])[C:56]=3[N:55]=[CH:54]1)[O:30]2)[CH2:32][O:33][Si](C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>O1CCCC1>[CH2:19]([O:26][C@@H:27]1[C@@:31]2([CH2:51][O:52][C@H:28]1[C@H:29]([N:53]1[C:68]3[N:67]=[C:60]([NH:61][C:62](=[O:66])[CH:63]([CH3:64])[CH3:65])[NH:59][C:57](=[O:58])[C:56]=3[N:55]=[CH:54]1)[O:30]2)[CH2:32][OH:33])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Komponenten

4

Edukt 2

HCID 2724141Tetrabutylammonium FluorideHCID 136344205HCID 136344205, Verbindung

Produkt 1

HCID 135405285HCID 135405285, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Tetrabutylammonium fluoride (1.0 M in THF, 0.90 ml, 0.90 mmol) was added, at room temperature, to a tetrahydrofuran solution (3.0 ml) of Compound 46 (41.3 mg, 0.060 mmol), and the mixture was stirred for 1 hour at room temperature. The reaction mixture was distilled under reduced pressure, and the resulting crude product was purified by silica gel column chromatography (AcOH-EtOH, 20:1) to obtain a white powder, Compound 47 (27.1 mg, 0.060 mmol, quant.).

Aufarbeitung

  1. distillationThe reaction mixture was distilled under reduced pressure
  2. customthe resulting crude product was purified by silica gel column chromatography (AcOH-EtOH, 20:1)

Quellen und Nachweise

ORD-Eintrag
ord-77f297bb79434ac6b5d29a0225f576c6
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06770748B2

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