Water → HCID 2794448, Verbindung

HRID 1835687Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1835687
[C:1](OC(C)(C)C)(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([O:21][CH3:22])[CH:20]=1)[NH2:17].CS(O)(=O)=O.O>C1(C)C(C)=CC=CC=1>[CH3:22][O:21][C:19]1[CH:20]=[C:14]([O:13][CH3:12])[CH:15]=[C:16]2[C:18]=1[C:3]([CH3:5])=[CH:2][C:1](=[O:6])[NH:17]2

Komponenten

6

Edukt 4

HCID 962WaterHCID 6395Methanesulfonic AcidHCID 15538Tert-butyl acetoacetateHCID 663013,5-Dimethoxyaniline

Produkt 1

HCID 2794448HCID 2794448, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Reaktionsbedingungen

Temperatur
125 °C

Versuchsvorschrift

tert-Butyl acetoacetate (1.58 g) was heated to 120° C. and 3,5-dimethoxyaniline (1.53 g) dissolved in xylene (4 ml) was added The mixture was heated at 120-130° C. for 20 minutes and then cooled to room temperature. Methanesulfonic acid (2 ml) was added and the mixture was stirred at ambient temperature for 10 minutes. Water (40 ml) was added and the precipitate filtered and dried. Yield 1.31 g (60%).

Aufarbeitung

  1. additionwas added The mixture
  2. temperaturecooled to room temperature
  3. filtrationthe precipitate filtered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-474de6f4f16d4f82961aa3bac26dbc04
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06774103B1

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