2-Bromo-4-(bromomethyl)benzenemethanol → 2-Bromo-4-(bromomethyl)benzaldehyde

HRID 1836750

Reaktionsgleichung

Reaktionsgleichung von HRID 1836750
[Br:1][C:2]1[CH:7]=[C:6]([CH2:8][Br:9])[CH:5]=[CH:4][C:3]=1[CH2:10][OH:11]>CCO.CCOC(C)=O.O=[Mn]=O>[Br:9][CH2:8][C:6]1[CH:5]=[CH:4][C:3]([CH:10]=[O:11])=[C:2]([Br:1])[CH:7]=1

Komponenten

4

Edukt 1

HCID 120160372-Bromo-4-(bromomethyl)benzenemethanol

Produkt 1

HCID 120160382-Bromo-4-(bromomethyl)benzaldehydeAusbeute 80,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 21584252Ethanol ethylacetateLösungsmittel

Versuchsvorschrift

The compound of Step 2 (8 g, 29 mmol, 1 eq) was dissolved in 10% EtOH/EtOAc (300 ml) and 5 eq of MnO2 (12.4 g, 142 mmol) was added every hour for 6 hours. The mixture was filtered through Celite and the solvent was removed under vacuum to give 6.5 g (80%) of the title compound.

Aufarbeitung

  1. filtrationThe mixture was filtered through Celite
  2. customthe solvent was removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-12aa8b69e8af4585a6345b4940b0c6b8
Quelldatensatz
uspto-grants-2004_08
Patentnummer
US06777433B2

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